The alternative subexpressions are separated by vertical bar(s) |.
Let us now change it to extract all lines including either human, rat or mouse proteins:
if ($line =~ /HUMAN|RAT|MOUSE/) { }
#match line against either HUMAN, RAT or MOUSE
if ($line =~ /ACM1_(HUMAN|RAT|MOUSE)/) { }
# we enclosed the alternative subexpressions in parentheses (HUMAN|RAT|MOUSE)
# and added the receptor name prefix ACM1_ before them.